1410-The BMP7-TGM2 Axis in Preeclampsia Pathogenesis

Paper Talk · Aug 9, 2026 · 23m

This research identifies a critical molecular connection between BMP7 deficiency and the development of preeclampsia (PE), a dangerous hypertensive disorder during pregnancy. Scientists discovered that BMP7, a growth factor usually abundant in the placenta, is significantly reduced in patients with PE, leading to an abnormal increase in TGM2 protein levels. Under normal conditions, BMP7 promotes healthy trophoblast invasion and placental formation by suppressing TGM2 through a specific intracellular signaling pathway. When this balance is disrupted, elevated TGM2 restricts the ability of…