Pharma 57: β-Lactams - Breaking the Wall Without Breaking the System
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This episode explores β-lactam antibiotics as the pharmacology of structural sabotage. By targeting cell wall synthesis-a feature humans do not possess-penicillins, cephalosporins, carbapenems, and related agents achieve extraordinary selective toxicity. We trace peptidoglycan assembly, penicillin-binding proteins, and bacterial autolysis to explain why…
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