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1632-X-ray Preactivated Nanoparticles for Deep Tumor

The research paper introduces ETPNs, a novel nanoparticle system designed to treat deep-seated pancreatic tumors using X-ray preactivated photodynamic therapy. These nanoparticles utilize persistent luminescence, allowing them to emit therapeutic light internally after external X-rays are removed, which avoids the risks of continuous radiation. A key feature of the technology is its reversible "on-off" mechanism, which activates the treatment specifically in the acidic microenvironment of a tumor while remaining inactive in healthy tissue. The system further integrates elimusertib, a drug…

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