322-Sensing of Mechanical Stress Governs Tissue Growth
The article explores the connection between mechanical forces, tissue density, and cellular growth control, establishing that membrane potential serves as a fundamental biophysical signal. The authors present a mechano-electro-osmotic model showing that compression leads to higher cytoplasmic biomass density, which physically couples to the cell membrane to induce hyperpolarization. Experimental results confirm that as epithelial tissues reach maximum density, cells become progressively more hyperpolarized and cease proliferation. This electrical signal directly regulates key growth pathways…
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