1292-Spatial Proteomics of Microglial States in AD
This research introduces CODEX-CNS, a specialized multiplexed protein imaging technology designed to map the complex cellular landscape of the human brain. By developing a custom protocol to eliminate tissue interference, the authors successfully profiled over 700,000 individual cells to study the progression of Alzheimer’s disease. The study identifies a specific group of human plaque-associated microglia that physically cluster around dense amyloid-β deposits. These findings demonstrate that a cell’s identity and behavior are heavily influenced by its local spatial neighborhood and…
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