1074-Spatial Topography Drivers of Interstitial Lung Disease

Paper Talk · Jun 3, 2026 · 20m

This study presents a multimodal atlas of interstitial lung disease (ILD) by integrating single-nucleus RNA sequencing and spatial transcriptomics to map the cellular landscape of pulmonary fibrosis. Researchers identified specific pathogenic cell communities, including pro-fibrotic fibroblasts and aberrant transitional epithelial cells, that drive the destruction of healthy lung tissue. The findings reveal that a combination of pro-inflammatory cytokines—specifically TGF-β, IL-1β, and TNF-α—triggers the maladaptive differentiation of these harmful epithelial states. Furthermore, the study…