1363-Cell State Dynamics in Colorectal Cancer
This research identifies TROP2 as a critical biomarker for poor-prognosis colorectal cancer, specifically marking a "fetal-like" cell state linked to metastasis and drug resistance. While traditional chemotherapy often induces these dangerous TROP2+ cell populations, the study demonstrates that antibody-drug conjugates (ADCs) can effectively target and eliminate them. Functional analysis reveals a high degree of cellular plasticity, where tumors shift between LGR5+ stem cells and TROP2+ states to survive therapeutic pressure. By combining standard chemotherapy with TROP2-directed ADCs, the…
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