1588-Microbial Engraftment & Immune Regulation in Cancer
This review article examines the role of fecal microbiota transplantation (FMT) in enhancing the effectiveness and safety of immune checkpoint inhibitors (ICIs) for cancer patients. The authors propose a two-stage model where successful treatment depends on clearing harmful recipient bacteria followed by the stable integration of beneficial donor microbes. Research indicates that specific microbial signatures, such as short-chain fatty acid producers, correlate with better tumor responses and reduced toxicity. Conversely, certain bacteria like Segatella copri may increase the risk of severe…
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