1177-A Spatiotemporal Atlas of Developing Human Meninges

Paper Talk · Jun 24, 2026 · 12m

The paper presents a spatiotemporal transcriptomic atlas of the developing human meninges during early-to-mid gestation. By utilizing single-cell RNA sequencing and spatial imaging, the researchers identify that the three meningeal layers develop asynchronously, with the pia mater forming first. The study highlights how pial fibroblasts use CXCL12-CXCR4 signaling to recruit and organize meningeal macrophages within the leptomeningeal zone. Furthermore, a specific population of Trem2+ macrophages is shown to regulate the development and continuity of Cajal-Retzius cells in the cerebral cortex…