149-Neuronal Communication and Alzheimer's Pathology
This research article introduces the discovery and characterization of dendritic nanotubes (DNTs), a previously unconfirmed nonsynaptic communication network in the brain that operates in parallel with traditional synapses. Using advanced microscopy on mouse and human brain tissue, the authors identified these ultrathin membrane bridges, which are formed by dendritic filopodia and confirmed to facilitate the intercellular transfer of substances like calcium ions. Crucially, the study demonstrates that DNTs act as direct conduits for the propagation of disease-related molecules, specifically…
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