1522-Targeting PIKfyve-ER Stress Axis in Prostate Cancer
This research article identifies PIKfyve as a highly expressed lipid kinase that serves as a critical survival factor for neuroendocrine prostate cancer (NEPC). The study reveals that NEPC cells utilize a PIKfyve-dependent pathway to manage high levels of endoplasmic reticulum (ER) stress and maintain metabolic stability. When PIKfyve is inhibited, the cancer cells launch a compensatory SREBP-driven lipogenesis program to survive the resulting cellular strain. By co-targeting PIKfyve and fatty acid synthase (FASN), researchers can disrupt this adaptive backup system and trigger widespread…
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