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The Accidental Pill: How a Mistake Created Oral Progestin Ethisterone
The Accidental Pill: How a Mistake Created Oral Progestin Ethisterone
A single chemical tweak in a Berlin lab in 1938 turned a would-be oral testosterone into the first orally active progestin, a pill that let women skip injections and take progesterone-like therapy at home-so how did a modification aimed at preserving androgenicity create a new drug no one had asked for?
In this episode, we tell the story of the Schering AG team and their unexpected discovery, tracing how an ethynyl group at C17α transformed testosterone chemistry into a medically useful progestin and asking what…
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