1535-NextGen DepMap: A 3D Cancer Model Dependency Resource
The paper describes the development and integration of Next-Generation (NextGen) cancer models, such as 3D organoids and spheroids, into the Cancer Dependency Map (DepMap). By conducting 147 genome-scale CRISPR screens and extensive multi-omic profiling, researchers found that these 3D models more accurately represent patient tumor lineages and genetic diversity than traditional 2D cell lines. These advanced models preserve critical gene expression programs, including glial states in brain cancer and mucinous differentiation in gastrointestinal tumors, which are often lost in conventional…
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