1247-Organ-Specific Proteomic Aging Clocks

Paper Talk · Jul 8, 2026 · 21m

This research introduces a novel framework of organ-specific proteomic aging clocks developed using machine learning and plasma protein data from over 43,000 individuals. By analyzing proteins enriched in ten major organ systems, the study demonstrates that biological aging is heterogeneous across the body and that accelerated organ aging can predict disease onset and mortality more accurately than chronological age. Specifically, a "brain aging clock" was identified as a powerful, noninvasive predictor of dementia and neurodegenerative decline, even showing the ability to identify resilience…