425-Extracellular GPX4 impairs antitumor immunity

Paper Talk · Jan 24, 2026 · 14m

This research identifies GPX4 as a critical immunosuppressive factor released during ferroptosis, a specific type of iron-dependent cell death. While many forms of cell death trigger immune responses, ferroptotic cells often fail to activate robust defenses because extracellular GPX4 binds to the ZP3 receptor on dendritic cells. This interaction triggers a cAMP-PRKA signaling pathway that inhibits glycolysis, thereby preventing the proper maturation and activation of these vital immune cells. Experiments demonstrate that blocking the GPX4-ZP3 axis can restore the effectiveness of anti-tumor…