Cellular Senescence Involves Gene Repression Through p53-p16/RB-E2F-DREAM Complex
A new research paper was published in Aging (Aging-US) Volume 15, Issue 10, entitled, “Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex.” Cellular senescence is a dynamic stress response process that contributes to aging. From initiation to maintenance, senescent cells continuously undergo complex molecular changes and develop an altered transcriptome. Understanding how the molecular architecture of these cells evolve to sustain their non-proliferative state will open new therapeutic avenues to…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.