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Jan Thirkettle - CEO Harness Therapeutics at BIO Boston 2025

From BIO Boston: Jan Thirkettle, CEO of Harness Therapeutics

In this episode, I sit down with Jan Thirkettle, a biotech leader with deep experience across gene therapy, platform innovation, and company-building.

Jan was part of the team that helped bring one of the first ex vivo gene therapies to market. Today, he’s leading Harness Therapeutics — a UK-based company developing a novel class of RNA therapeutics (MISBA tech) to upregulate protein expression with unprecedented precision.

We talk about:— Why Harness is targeting neurodegeneration and CNS— The company’s unique approach to hitting…

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