1119-Regenerative Skin Remodeling in Systemic Sclerosis
This research examines the transformative effects of CD19-CAR T cell therapy on patients with systemic sclerosis (SSc), a severe autoimmune disease marked by debilitating skin fibrosis and vascular damage. Utilizing advanced deep phenotyping techniques like spatial transcriptomics (cISH) and imaging mass cytometry (IMC), the study demonstrates that the treatment can actually regenerate complex skin structures, such as dermal papillae, which were previously considered permanently lost. Analysis of skin biopsies reveals a profound shift in fibroblast populations, moving from a…
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