Latest / The You Project / #2202 A Cure For MND? - David Gillespie

Transcript

#2202 A Cure For MND? - David Gillespie · The You Project

0:00
Speaker 1: I got our team. That's Harps and Bloody Davo from
0:03
Speaker 1: the Sunshine State. It's of course David Gillespie, Craig, Anthony Harper.
0:07
Speaker 1: San's tiff. There is no tiff, not a tiff insight,
0:10
Speaker 1: not a tiff to be seen. We are completely tifless,
0:13
Speaker 1: which makes David a little bit sad.
0:16
Speaker 2: Yes, indeed, but that's what I had me too, of course.
0:19
Speaker 2: Tiff Ah, I'm sure she's listening.
0:23
Speaker 3: She's got nothing better to do to listen to us.
0:25
Speaker 1: Yeah, that's true. Oh what do you do in your
0:28
Speaker 1: spare forty minutes? I listened to those two fucking idiots. Yeah, yeah, no,
0:33
Speaker 1: probably not. She's probably never.
0:34
Speaker 3: I love it so much. I listened to them even
0:36
Speaker 3: when I'm not being paid to listen to them.
0:39
Speaker 2: That's true. Good point.
0:42
Speaker 1: Okay, you make a valid point, all right. Self esteem
0:45
Speaker 1: back in check, self worth just in the gutter again.
0:50
Speaker 3: All right.
0:50
Speaker 1: So we're going to talk about like this is quite
0:52
Speaker 1: a topical conversation, you said to me before we went live.
0:55
Speaker 1: It's a little bit technical. So the audience and I
0:59
Speaker 1: although some of that. We might have a whole lot
1:01
Speaker 1: of people who are all over this, but for those
1:04
Speaker 1: of you who aren't and MOI myself, well, hang on
1:08
Speaker 1: as best we can. But what is called als and
1:13
Speaker 1: wasn't it called lou Gerrigg's disease at some stage as well?
1:17
Speaker 3: Yeah, And that's I think it's still easy in the
1:20
Speaker 3: US because they know who lou Grigg is.
1:23
Speaker 1: Yeah, famous historically famous baseballer who got what we call
1:28
Speaker 1: an Australia MND mode in your own disease. And of
1:31
Speaker 1: course I don't know how much his pr the right word,
1:36
Speaker 1: but attention is probably the right word that it gets
1:39
Speaker 1: through the media in Coinsland, but it's quite a lot
1:42
Speaker 1: of Victoria. I think I've said this to you before
1:44
Speaker 1: because Neil danaher Rip, great footballer, great coach of the
1:50
Speaker 1: Melbourne Football Club, passed away recently and he outlived the
1:57
Speaker 1: the average life expect and see which you'll tell me,
2:01
Speaker 1: but I feel like it's around one and a half
2:03
Speaker 1: to two years or they'reabout sea outlived it by I
2:07
Speaker 1: think nine or nine and a half. I think he
2:08
Speaker 1: got up eleven twelve years, which was amazing. But he's
2:12
Speaker 1: been the face of the big freeze it's called down
2:16
Speaker 1: here in Victoria and around Australia for that matter, And
2:21
Speaker 1: so it's a disease that has gotten not more attention
2:26
Speaker 1: than it deserves, that's for sure, but compared to other diseases,
2:29
Speaker 1: a disproportionate amount of attention. And it's funny that we're
2:33
Speaker 1: talking about this because I'm pretty sure that the Big
2:37
Speaker 1: Freeze has raised over one hundred million dollars. And I
2:41
Speaker 1: literally asked this someone the other day. I said, I wonder,
2:45
Speaker 1: and this is not a cynical question, but I wonder
2:48
Speaker 1: what the ROI is on that hundred plus million dollars.
2:52
Speaker 1: I wonder if there has been and if there has,
2:55
Speaker 1: what it is, what progress has been made in terms
2:58
Speaker 1: of research and moving towards some kind of cure or
3:02
Speaker 1: at the very least effective treatment.
3:04
Speaker 2: So do you know?
3:05
Speaker 3: Do you know? Yeah, well, not much is probably the answer.
3:11
Speaker 3: But that's generally the case with a lot of medical research,
3:14
Speaker 3: particularly the big name stuff, you know, where there's lots
3:17
Speaker 3: of fundraising and so on. I'm not a giant fan
3:20
Speaker 3: of raising, you know, these sort of fundraising things for
3:25
Speaker 3: medical research. My view is that medical research should be
3:29
Speaker 3: being paid for by the taxpayer, not by charities, and
3:35
Speaker 3: not by drug companies. Unfortunately, our governments tend to have
3:41
Speaker 3: a different view from that, and it's a view that
3:43
Speaker 3: has resulted in the shrinking of how much taxpayer funds
3:46
Speaker 3: are sent towards R and D, not the grow growing
3:49
Speaker 3: of it. The reason for that is that research and
3:54
Speaker 3: development isn't a thing that you can just sit down
3:57
Speaker 3: and say, I'm only funding this if it gets me something.
4:01
Speaker 3: Of course, it's nature. It's we don't know if there's
4:05
Speaker 3: an answer. Let's try a bunch of stuff and see
4:09
Speaker 3: if we can find out.
4:11
Speaker 2: Yes, And.
4:14
Speaker 3: That is sort of resistant to the notion of we're
4:18
Speaker 3: only paying for this if good stuff is produced.
4:21
Speaker 2: Well, there's another spot.
4:22
Speaker 1: I mean, there's also like I just think, like you know,
4:26
Speaker 1: I've donated, which I'm happily doing and will continue to do.
4:30
Speaker 1: But at some stage you think, oh, it's been like
4:32
Speaker 1: ten to eleven years, has been one hundred plus million dollars.
4:35
Speaker 1: It's not like you know what am I getting from
4:38
Speaker 1: my money. It's just curiosity. It's like, has there been
4:42
Speaker 1: any movement of the needle in the direction of something positive?
4:46
Speaker 1: That's for me. It's just about curiosity. It's not about
4:49
Speaker 1: some kind of audit on the work. You know, it's
4:53
Speaker 1: just that. But it doesn't seem to be anything forthcoming.
4:57
Speaker 3: Well except talk about some very recent studies today that
5:04
Speaker 3: are funded from things like that, which do seem to
5:08
Speaker 3: be producing some results. And that's quite different. I mean,
5:13
Speaker 3: M and D in Australia is growing out of control.
5:19
Speaker 3: The stats are pretty significant. It is tripled. So between
5:27
Speaker 3: over what time, Yeah, I'm just going to say between
5:29
Speaker 3: the nineteenth mid nineteen eighty So between nineteen eighty six
5:35
Speaker 3: and twenty twenty three, MND deaths grew from two hundred
5:40
Speaker 3: and thirty eight to seven hundred and eighty one in Australia.
5:45
Speaker 3: That's per annum. I mean, that's disproportionately low compared to,
5:52
Speaker 3: like you say, the publicity that the disorder gets. There
5:56
Speaker 3: are certainly things that kill a lot more Australians than that,
5:59
Speaker 3: but nevertheless, the growth rate is pretty massive For something
6:06
Speaker 3: to triple says there's something going on. This is not
6:10
Speaker 3: a case of better diagnosis or anything. You know, there's
6:13
Speaker 3: no doubt when someone has m ND it's paralysis. You know,
6:18
Speaker 3: it's a MEND. By the way, stands for motor neurone disease,
6:22
Speaker 3: and the disease we're talking about is that the motor
6:24
Speaker 3: neurone stop working, so and if you know anything about biology,
6:31
Speaker 3: no motor neurons, no moving anything, including breathing, so you
6:37
Speaker 3: know it's it's a catastrophic disease. The official position on
6:41
Speaker 3: it at the moment is there is no cure. You know,
6:45
Speaker 3: once diagnosed with this thing, the outcome is absolutely certain,
6:50
Speaker 3: and that is that you will be progressively paralyzed. So
6:55
Speaker 3: it's it's a really heartbreaking disease. But there are some
7:04
Speaker 3: interesting studies done very recently. One that was published in
7:10
Speaker 3: April twenty twenty six. It was a study of one hundred.
7:15
Speaker 3: It was a US study, so they call them ALS
7:17
Speaker 3: there rather than MND. It's the same thing. MND is
7:22
Speaker 3: more of an umbrella. Term ALS is the biggest variant.
7:28
Speaker 3: One hundred studies one hundred patients, And what they were
7:30
Speaker 3: looking at in those patients is they're looking at the
7:34
Speaker 3: blood work of those people as they progressed from diagnosis
7:38
Speaker 3: to death and monitoring a whole bunch of markers in
7:41
Speaker 3: their blood. And what they found was there there was
7:45
Speaker 3: a whole lot of things that correlated, you know, things
7:47
Speaker 3: that got worse over time. But what they found is
7:51
Speaker 3: all of them plataued at a certain point. So yes,
7:54
Speaker 3: they were getting worse. But then at a certain point
7:56
Speaker 3: they just plataed. There was one real noticeable exception, and
8:02
Speaker 3: that was a molecule called for HNE. So for hn E,
8:09
Speaker 3: which is its nickname. It actually stands for four hydroxo nonenol.
8:13
Speaker 3: I think, and even that's a shortening of its real name.
8:17
Speaker 3: Is a pretty bad actors. Now we've talked before about it.
8:24
Speaker 3: It is what's called an aldehyde, which means it reacts
8:28
Speaker 3: pretty aggressively with proteins and other bits and pieces in
8:32
Speaker 3: the human body. You'd be more familiar, I guess with
8:36
Speaker 3: things like a settle aldehyde, which is the one you
8:37
Speaker 3: get from alcohol, or acrolene, which is the dominant one
8:41
Speaker 3: in cigarette smoke. So those are the things that make
8:45
Speaker 3: booze and Ciggi's bad for you is that they contain
8:49
Speaker 3: these aldehydes which produce really bad effects when they react
8:53
Speaker 3: with bits and pieces in the human body, notably things
8:56
Speaker 3: like DNA and proteins and so on. They tracked in
9:02
Speaker 3: this study, and they found that unlike everything else that
9:04
Speaker 3: they tracked, as these people were progressing towards death, it
9:09
Speaker 3: just kept going up, just kept going up and up
9:13
Speaker 3: and up. It actively predicted the speed of their paralysis
9:17
Speaker 3: and the length of their survival. So the higher the
9:21
Speaker 3: four AHNE was, the less time you had And there's
9:25
Speaker 3: a really good biochemical reason for that, which they ultimately
9:28
Speaker 3: discovered and we're going to talk about later, but that
9:33
Speaker 3: was an interesting point. It was the first really big
9:36
Speaker 3: study in humans which showed that this molecule for HNE
9:41
Speaker 3: would predict how long you had left on this earth
9:45
Speaker 3: if you had MND and a drug company sponsoring the study.
9:50
Speaker 3: Obviously it occurs to them to think, hmm, what if
9:54
Speaker 3: we could get rid of that for HNE.
9:57
Speaker 2: Seems like a good ideas, be a.
10:00
Speaker 3: Good thing, and so there's now what's called so there's
10:05
Speaker 3: a company called Coir Therapeutics in the United States now
10:09
Speaker 3: recruiting patients to what's called the Phase two trial in
10:11
Speaker 3: humans where they are seeing if they can come up
10:15
Speaker 3: with ways to do exactly that, so drugs that will
10:19
Speaker 3: get rid of the four HNE. And they're thinking, it's
10:23
Speaker 3: pretty obvious if four h and E is actual, is
10:27
Speaker 3: you know, really accurately predicting the demise of this person,
10:33
Speaker 3: then what if we introduce some chemical that gets through
10:36
Speaker 3: to four hne okay.
10:38
Speaker 1: On hound, So are they thinking or you're maybe going
10:42
Speaker 1: to say this that's going to maybe slight the progression,
10:44
Speaker 1: maybe be ap the brakes on altogether, or possible.
10:47
Speaker 3: Or stop it or even curer. Yeah, so you know,
10:53
Speaker 3: the sky's the limit here. And that's why they're doing
10:54
Speaker 3: trials on this. So you asked you for what are
10:57
Speaker 3: they doing with my research money? This is some of
10:59
Speaker 3: the things they're doing with your research money.
11:02
Speaker 2: I didn't ask everyone. I'm all for the research under
11:09
Speaker 2: the butt.
11:12
Speaker 3: The interesting thing is I love reading drug trials because
11:16
Speaker 3: drug trials they don't get up caught up in ideology.
11:19
Speaker 2: Right, they're so glad you've got it. I'm so glad
11:22
Speaker 2: you've got a wife, because you would never get another one.
11:26
Speaker 3: Well, they just said they don't get caught up in ideology.
11:29
Speaker 3: They don't care what the doctrines are or what the
11:31
Speaker 3: dietitians are or or you know, whether whether you be
11:35
Speaker 3: saying this or that. They don't care. All they care
11:37
Speaker 3: about is does this thing work?
11:40
Speaker 2: And what with you?
11:41
Speaker 3: What is the thing we are trying to fix here?
11:43
Speaker 3: And can we fix it?
11:45
Speaker 2: We did? What was the outcome? We did this thing?
11:49
Speaker 2: And here's the data?
11:50
Speaker 3: Yeah, yeah, yeah, So they looked at that first trial,
11:54
Speaker 3: and they said, look, the hire the for hn E
11:56
Speaker 3: was in the in the patient's blood, the faster they
11:59
Speaker 3: lost the ability to walks, can breathe. And they're now
12:02
Speaker 3: looking at this and the people in the second trial
12:05
Speaker 3: and saying, okay, well, let's get something that takes that
12:08
Speaker 3: out and see what happens. Do you know, our worst
12:13
Speaker 3: case scenario might be that the person gets to live
12:15
Speaker 3: a bit longer, but there might be much better scenarios
12:18
Speaker 3: than that as well, where you know, effectively we cure them.
12:22
Speaker 3: So you might be thinking, oh, hang on, I said
12:27
Speaker 3: before that we've talked about this molecule before, and we
12:32
Speaker 3: certainly haven't talked about MND or these drug trials before.
12:35
Speaker 3: So why would we have been talking about this molecule
12:38
Speaker 3: Because there is only one source of this molecule in nature,
12:43
Speaker 3: only one, and that is seed oils. So it comes
12:48
Speaker 3: from a mega six everything weird.
12:52
Speaker 2: How much damage that shit does?
12:56
Speaker 3: Yeah, so the only place you're going to get four
12:58
Speaker 3: and four AHEN in your bloodstream is from oxidization of
13:04
Speaker 3: amiga six fat in seed oils. So do you think
13:09
Speaker 3: I know this is By the way, everyone, neither of
13:11
Speaker 3: us are medical experts, especially me, but Hypothetically, let's say
13:17
Speaker 3: somebody who was in the early stages, and again this
13:20
Speaker 3: is just guessing and talking, but if they went on
13:24
Speaker 3: a diet sands seed oils, so no seed oils or
13:28
Speaker 3: anything resembling seed oils are totally one seed oil free diet,
13:35
Speaker 3: that'd be interesting to see how.
13:36
Speaker 2: That moved the needle, because that eliminates this.
13:40
Speaker 3: It would The only problem is that the seed oils
13:43
Speaker 3: in your body today are the ones you wait two
13:46
Speaker 3: years ago. We very aggressively hang on to the fats
13:51
Speaker 3: in seed oils because it's the only fat we can't
13:54
Speaker 3: make ourselves, so in very very small quantities, we need
13:59
Speaker 3: this stuff to our immune system, to a whole bunch
14:02
Speaker 3: of things, and humans, like all vertebrates, can't make these fats.
14:09
Speaker 3: Only plants can make them, and because of that we
14:14
Speaker 3: need to get them from our fod. Suply, we have
14:16
Speaker 3: no trouble getting the microscopic amounts we need from just eating.
14:20
Speaker 3: It's when we overdose on them by eating a modern
14:23
Speaker 3: diet that has seed oils in everything that it becomes
14:26
Speaker 3: a problem. The trouble is our body doesn't know that's
14:29
Speaker 3: a problem. It just thinks it's landed in a green pasture, right,
14:32
Speaker 3: and oh, I'm supposed to I'm supposed to keep that
14:35
Speaker 3: stuff and keep it for a long time. Fortunately, there's
14:40
Speaker 3: a lot of it coming in and so what our
14:43
Speaker 3: body does is fill our fat stores with it. Now
14:47
Speaker 3: we've briefly mentioned this before, and we'll pro'll probably write
14:49
Speaker 3: a piece about it one day, But this is why
14:52
Speaker 3: women who are about to have children shouldn't consume seed oils. Well,
14:58
Speaker 3: not about to, but in general. So the fat that
15:02
Speaker 3: makes up a child's brain starts out its life in
15:07
Speaker 3: the mother's bottom. So the buttock fat becomes the child's brain.
15:12
Speaker 3: And you might think there's.
15:15
Speaker 1: A headlight, there's a headline you're not going to get
15:17
Speaker 1: anywhere else. Yeah, so it becomes her brain. Think about that.
15:24
Speaker 3: Well, and there's a reason for it. It's about temperature.
15:27
Speaker 3: So the further see phily unsaturated fats like seed oils combusted,
15:33
Speaker 3: you know, react at higher temperatures. And the human body
15:37
Speaker 3: is running at a pretty reasonably high temperature as far
15:39
Speaker 3: as these fats are concerned, at about thirty seven and
15:41
Speaker 3: a half degrees. So it's a good idea to store
15:44
Speaker 3: it as far away from that temperature as you can.
15:46
Speaker 3: So the coolest parts of the female human body, you know,
15:51
Speaker 3: the buttocks, and you know the arm fat and the breasts.
15:56
Speaker 3: So just because it's further away from the central heating system,
16:00
Speaker 3: the human torso.
16:01
Speaker 2: So authorized by Pillespie, men have no.
16:06
Speaker 3: Need to store fat at those distances because they're not
16:10
Speaker 3: trying to preserve it in any way. So that's why
16:12
Speaker 3: typical fat distribution on men is on the torso. So
16:17
Speaker 3: you know the reason for that is they're preserving the
16:21
Speaker 3: fat that really really valuable and rare stuff from an
16:25
Speaker 3: evolutionary perspective, these poly unsaturated fats that would have been
16:30
Speaker 3: really hard to come by. They're really handy to have
16:32
Speaker 3: if you need to build a human brain, because the
16:34
Speaker 3: human brain consists mostly of them. So if you need
16:39
Speaker 3: to make a human brain, it'd be really good to
16:41
Speaker 3: have put away quite a good deal of poly unsaturated
16:45
Speaker 3: fat and stored it as cool as you possibly can.
16:50
Speaker 2: So you're saying that like literally for that seed oils.
16:55
Speaker 1: Are required, Yes, yes, wow, but you don't need to
16:59
Speaker 1: go I never here the day, I never thought of that.
17:03
Speaker 3: You you don't have to go out of your way
17:04
Speaker 3: to do it, because the average female is not having
17:07
Speaker 3: a child until well, I mean, it's varied over time,
17:10
Speaker 3: but you know, roughly twenty years on this earth minimum,
17:13
Speaker 3: and in that twenty years they've accumulated enough to create
17:17
Speaker 3: a reasonable brain. Yeah, so it's that's all by design.
17:24
Speaker 3: The trouble is, of course, I mean we can talk
17:27
Speaker 3: about this another time. Is if you mess up the
17:29
Speaker 3: ratios and there's too much Amiga six and two little
17:32
Speaker 3: Omega three, then you get all kinds of problems with
17:34
Speaker 3: the brains that you make with these fats. But that's
17:37
Speaker 3: a that's a different thing for a different day. How
17:41
Speaker 3: did we get to there? Okay?
17:43
Speaker 1: So I just want to say to our audience at hey,
17:45
Speaker 1: can I just say this how the audience harps here?
17:49
Speaker 1: If you're confused, me too, So let's just keep listening together,
17:56
Speaker 1: all right.
17:56
Speaker 3: So you you said, would it be a good idea
17:59
Speaker 3: to stop eating oils if you don't want to be
18:02
Speaker 3: creating a lot of four H and E in your system? Yes,
18:04
Speaker 3: it would. Yes. The trouble is stopping now means in
18:08
Speaker 3: two years time you'll have an effect, because that's how
18:11
Speaker 3: long we hang on to seed oils. The chip you
18:13
Speaker 3: eat today you'll be carrying around for two years. So
18:18
Speaker 3: the yes is the simple answer, And from a drug perspective,
18:23
Speaker 3: we're about to find out if you aggressively try and
18:25
Speaker 3: do that some other way by putting it putting in
18:27
Speaker 3: place drugs that get rid of the four H and E,
18:29
Speaker 3: which is what they're going to try and do, then
18:32
Speaker 3: you might be able to do it a lot quicker.
18:35
Speaker 3: But for us out here in the world who don't
18:38
Speaker 3: have access to trial drugs like that, yes, your solution
18:41
Speaker 3: seems logically to be a smart one, which is reduce
18:45
Speaker 3: the four HNE by not consuming as much of the
18:48
Speaker 3: stuff that makes it. Now, I think it's really interesting
18:51
Speaker 3: to have a look at the actual architecture of MND,
18:55
Speaker 3: how the disease works, and why four HNE might be
18:59
Speaker 3: the cause of this problem, because it's all well and
19:02
Speaker 3: good to notice something like, oh, you know they have
19:05
Speaker 3: more four HNE and therefore you know that's a bad thing.
19:08
Speaker 3: If that was all they were going on, I'd say
19:10
Speaker 3: to you, oh, well, that's very interesting and maybe a
19:13
Speaker 3: reason to look further. But it's not in and of
19:16
Speaker 3: itself definitive that it might be causing it. You've got
19:19
Speaker 3: to have a real mechanism here for why that might occur.
19:23
Speaker 3: And it turns out there is one and a really
19:26
Speaker 3: convincing one. So what happens when now you'll know this
19:30
Speaker 3: because you know you're a gym junkie. In order in
19:33
Speaker 3: order to make a muscle move, you need a motorneuron
19:38
Speaker 3: to transmit a signal, and the particular molecule it uses
19:43
Speaker 3: to transmit a signal is something called glutamate.
19:46
Speaker 1: So it.
19:49
Speaker 3: Pumps glutamate across the gap from the motor neuron to
19:54
Speaker 3: the muscle to the receiver, and the receiver has muscle fibers,
19:59
Speaker 3: has receptors which which receives the glutamate signal and says, okay,
20:05
Speaker 3: good to go. I'm supposed to do something, and do it.
20:10
Speaker 3: Glutamate is really really powerful as a transmitter, and you
20:13
Speaker 3: can't just leave it there. You can't just spray it
20:16
Speaker 3: out and you know, the muscle pick it up when
20:18
Speaker 3: it needs it. That's not the way it works. It's
20:20
Speaker 3: got to be gone instantly. So the signal has to
20:23
Speaker 3: be transmitted and then the transmitting molecule, glutamate, has to
20:26
Speaker 3: be gone instantly. So of course we have a system
20:31
Speaker 3: for doing that, and there's a there's a thing called
20:36
Speaker 3: an eat to transporter e A a T two transporter,
20:41
Speaker 3: which is essentially a vacuum cleaner. It runs around sweeping
20:45
Speaker 3: up all the excess glutamate so it gets out of
20:48
Speaker 3: the gap immediately, and so it turns off the transmission
20:51
Speaker 3: signal because what you don't want to do is have
20:54
Speaker 3: the mode in your own jammed in on and that's
20:58
Speaker 3: what would happen if the gluten wasn't cleaned up instantly.
21:02
Speaker 3: So you want it to go bang hit and then off,
21:06
Speaker 3: bang hit and then off. You don't want it to
21:08
Speaker 3: stay jammed on, and so these EAT two things go
21:12
Speaker 3: around and clean it all up. The problem is that
21:16
Speaker 3: for hn E because it's a really nasty little thing.
21:21
Speaker 3: And this is what aldehydes do is they bind to
21:24
Speaker 3: all sorts of stuff in the human body, and one
21:27
Speaker 3: of the things that binds to is EAT too transporters
21:32
Speaker 3: and clog them all up and wreck them. Essentially, So
21:37
Speaker 3: when there's too much four hn E the in the
21:41
Speaker 3: spinal cord and in the brain, the EAT two transporters
21:46
Speaker 3: are smashed or clogged up and the glutamate can't be cleared,
21:51
Speaker 3: which means the motor in your own stays jammed at on,
21:56
Speaker 3: jam it a on for too long, and you wreck
21:58
Speaker 3: it and break it, destroy it. So it's that simple.
22:03
Speaker 2: Now it's that simple. Hey everyone, let's laugh together.
22:10
Speaker 3: I have put a handy dandy picture of how all
22:12
Speaker 3: this works. The article.
22:14
Speaker 1: Yeah, I like, you know what, my favorite sentence in
22:16
Speaker 1: the article. But there is a glaring multi billion dollar
22:19
Speaker 1: elephant in the neurology in the neurology clinic.
22:23
Speaker 2: I love that.
22:24
Speaker 1: And there is a very so this in substack everyone
22:27
Speaker 1: the article, and it's if you like me a little
22:30
Speaker 1: bit more visual.
22:33
Speaker 2: That is, did you create that?
22:35
Speaker 3: Like? Did you I told A to create that?
22:38
Speaker 2: Yeah, yeah, yeah, what I mean?
22:39
Speaker 3: Yeah, I'm not a cartoonist.
22:42
Speaker 2: I didn't mean did you hand draw it?
22:46
Speaker 3: I actually find that's one of the most useful uses
22:48
Speaker 3: of AI. He's being able to do cartoons, because all
22:51
Speaker 3: through my life I've thought, oh, wouldn't be a really
22:53
Speaker 3: smart cartoon if I didn't like that, And then then
22:55
Speaker 3: I've you know, I've suffered by my inability to actually draw.
23:00
Speaker 2: Well, now you don't need to. So that just saved
23:02
Speaker 2: yourself some time.
23:04
Speaker 3: Yeah, and some clarity for anyone who wanted to understand
23:08
Speaker 3: what I was drawing. Okay, so we've got a mechanism,
23:12
Speaker 3: we've got a culprit. We've got a drug trial underway
23:15
Speaker 3: to figure out if we get rid of this four
23:17
Speaker 3: h and E, do we actually extend people's lives. That
23:20
Speaker 3: should be enough. That should be enough for most of
23:25
Speaker 3: us out here in the real world to do the
23:27
Speaker 3: one thing we can do if we don't want MND,
23:31
Speaker 3: which is stop eating seed oils. Easier said than done.
23:37
Speaker 3: You know, you and I have talked before about your
23:39
Speaker 3: hunt for mayonnaise, but that's just the tip of the iceberg.
23:43
Speaker 3: You know, Mayonnaise, which should consist of olive oil and
23:46
Speaker 3: an egg, does not in most products sold on supermarket shelves.
23:52
Speaker 3: And it's very typical. Almost everything on the supermarket shelf
23:57
Speaker 3: is full of seed oil. You have to work really
23:59
Speaker 3: hard to avoid it, and even harder now that they've
24:03
Speaker 3: mandated that all the fast food joints and all the
24:06
Speaker 3: takeaway stores all fry everything in it. Yes, so it's
24:12
Speaker 3: really important.
24:13
Speaker 2: Advertise, you know.
24:14
Speaker 1: They advertise it like on the front of near me
24:17
Speaker 1: there's a fish and chip shop, and splashed across the
24:20
Speaker 1: window like at some kind of pr exercise.
24:25
Speaker 2: It says vegetable oil cooked in vegetable oil.
24:28
Speaker 3: I'm like, well, it is a pr exercise. It's it's
24:31
Speaker 3: a health message that the Heart Foundation has been championing
24:34
Speaker 3: for decades. Yeah and uh, and that's another line I
24:42
Speaker 3: use in here with you know, you probably didn't read
24:43
Speaker 3: this far, but towards the end of the.
24:45
Speaker 2: Article, oh is there an end?
24:48
Speaker 3: Oh? Okay, I say, you cannot extinguish a biological fire
24:53
Speaker 3: while the dietary high priesthood actively mandates that you swallow
24:56
Speaker 3: the gasoline. And that's what's going on. They're you know,
25:03
Speaker 3: they're telling you this is something you should eat when
25:06
Speaker 3: it's exactly the opposite of that, and the science over
25:08
Speaker 3: and over and over again proves that. But still just
25:13
Speaker 3: try and buy food without seed oil in it. It
25:16
Speaker 3: is very, very difficult. One of the things I do
25:19
Speaker 3: is periodically on my sub stack, I do publish lists
25:23
Speaker 3: of like you know, I'm about to do one, I
25:25
Speaker 3: think of one of the fast fruit. I think I'm
25:27
Speaker 3: going to do Goodman and gome Is. If I haven't already,
25:29
Speaker 3: I have to check that. Just go through their menu
25:32
Speaker 3: and say, Okay, this one's fine, this one's not based
25:35
Speaker 3: on because a lot of these places do publish pretty
25:38
Speaker 3: thorough lists of what's in their food.
25:40
Speaker 2: Yeah.
25:41
Speaker 1: Yeah, So is there any timeline on this research and
25:48
Speaker 1: like where we're getting vaguely close to human trials?
25:52
Speaker 3: Well, it's a I think did I say it was
25:55
Speaker 3: a Tier two trial? Yeah, you did so, yeah two,
26:00
Speaker 3: it's phase three before you're at a stage where you're
26:04
Speaker 3: coming up towards some sort of a certification. So I'd
26:06
Speaker 3: say we're years off. Honestly, it's interesting reading because of
26:12
Speaker 3: the mechanism that they're exploring, and these trials are not cheap.
26:17
Speaker 3: You know, you do a trial of one hundred people,
26:19
Speaker 3: that's something that is not cheap at all. And so
26:25
Speaker 3: I guess circling back to what you said before, is
26:27
Speaker 3: what are they doing with this research money? Well, this
26:29
Speaker 3: is the kind of thing they are doing. But also
26:31
Speaker 3: drug companies are pumping their own money into it because, clearly,
26:35
Speaker 3: from their perspective, having something that cures MND, or at
26:39
Speaker 3: least significantly prolongs your lifespan if you have it, is
26:45
Speaker 3: a highly marketable substance.
26:48
Speaker 2: Yeah yeah, yeah, yeah, Well.
26:50
Speaker 3: I can give you one for free right now. Don't
26:53
Speaker 3: eat seed oils.
26:58
Speaker 1: I think that's a a true piece of advice for
27:02
Speaker 1: a lot of things or a lot of conditions.
27:03
Speaker 3: Right, Yep, it is, and we'll go through them one
27:06
Speaker 3: by one eventually, but I just wanted to do that
27:10
Speaker 3: one because you asked me about it at the end
27:12
Speaker 3: of the last show, and you know, you drive my research, Craig.
27:15
Speaker 3: You give me the ideas for what people want to know.
27:19
Speaker 1: I'm the ideas guy. But honestly, everyone I know, that's
27:25
Speaker 1: that's a lot I know. But it's on Goalspo's substack.
27:29
Speaker 1: It's July five. It's called the ice Bucket Paradox, and
27:34
Speaker 1: it is like I actually think, especially the the SEC
27:40
Speaker 1: and the healthy sign apps, the one at the top
27:43
Speaker 1: there in mind pathology, that second.
27:48
Speaker 2: Image, that's fantastic.
27:50
Speaker 3: The diagram of how it all works.
27:51
Speaker 2: Yeah, yeah, yeah, that's fantastic.
27:54
Speaker 1: So I mean some of this stuff, I mean, here's
27:59
Speaker 1: the thing with some of this stuff, Like I think
28:01
Speaker 1: for a lot of people, a lot of our listeners anyway,
28:05
Speaker 1: the starting point is the podcast.
28:07
Speaker 2: It's like, you're not going to learn it here, you're
28:09
Speaker 2: going to hear about it here, you're not going to
28:11
Speaker 2: remember it.
28:12
Speaker 1: Probably you remember some stuff, but using the article or
28:16
Speaker 1: using the podcast as a kind of an opening of
28:19
Speaker 1: the door into a little bit more research and understanding,
28:22
Speaker 1: Like for me, that's the point, is like, let's talk
28:25
Speaker 1: about something, let's share some thoughts and ideas and science,
28:29
Speaker 1: and if you want to dig deeper, if you were
28:32
Speaker 1: going to go from this point one, I would read
28:33
Speaker 1: the article, which is probably easier to consume in that
28:40
Speaker 1: you can go back and forth and you can look
28:44
Speaker 1: at the graphics and see what's going on. But then
28:47
Speaker 1: beyond that, you know, like I wrote down here for
28:52
Speaker 1: myself alder Hydes because I just need to I need
28:56
Speaker 1: to go learn more about that, because I kind of
29:00
Speaker 1: know what you're talking about because you've spoken about it
29:03
Speaker 1: a bit. But I'm like, yeah, I need to. I
29:06
Speaker 1: need to go and do my own research because this
29:08
Speaker 1: is not my area of expertise.
29:10
Speaker 3: Yeah, and maybe I should do a bit of an
29:12
Speaker 3: explainer article on aldehyde. So yeah, it's it's I agree,
29:18
Speaker 3: it's a starting point. And even the article I wrote
29:20
Speaker 3: is a starting point in that you know, some of
29:23
Speaker 3: your listeners might read through that and say, oh, well,
29:24
Speaker 3: I actually want to go and read this study. Well,
29:27
Speaker 3: if you do, get in the comics, ask me for it,
29:29
Speaker 3: and I'll give you whatever you want in terms of
29:32
Speaker 3: links to whatever you want to see. None of it's
29:35
Speaker 3: made up believe me, I can give you the actual
29:37
Speaker 3: studies if you're that way in twined.
29:40
Speaker 1: Also, while we're at it, everyone if obviously there's no hooks, catches,
29:46
Speaker 1: genders or finance attached to this, but if you want
29:48
Speaker 1: to jump into the you Project Facebook group, which we have,
29:55
Speaker 1: it's not huge, but it's four and a bit thousand
29:58
Speaker 1: people and a lot of people in there. Very he
30:00
Speaker 1: consistent and always asking good questions and coming up with ideas.
30:04
Speaker 1: But when this is published, it'll be up in that page.
30:10
Speaker 1: On that page, jump into the comments. And if you
30:14
Speaker 1: want David to explore something, obviously you can't do everything,
30:19
Speaker 1: but there's something that you want to know in their
30:21
Speaker 1: space and you kind of get the general vibe of
30:23
Speaker 1: our conversations and topics. Just leave it there and if
30:27
Speaker 1: he doesn't see it, I'll bring it to his attention
30:30
Speaker 1: and you might be the genesis for a whole new podcast.
30:33
Speaker 2: So there's that that you can do.
30:37
Speaker 3: Yeah. Oh, and also this week I put off another video.
30:41
Speaker 3: This one's about why what we're told about Salty's nonsense.
30:46
Speaker 2: I shared it. I shared it.
30:47
Speaker 3: Yeah. See, there you go through.
30:50
Speaker 2: And I don't want to say I was solely responsible
30:53
Speaker 2: for the success.
30:53
Speaker 4: But I mean, I mean, no, you know what on
30:58
Speaker 4: my page that's at that is that eleven thousand, two
31:07
Speaker 4: hundred views.
31:08
Speaker 2: That's a lot.
31:09
Speaker 3: He's got a bad Yeah, okay, I'll I'll give.
31:14
Speaker 1: You the insights right here. Eleven two seven seven views,
31:20
Speaker 1: seventy two comments, thirty seven shares, twenty two saves, and
31:28
Speaker 1: two people put it up on their own page, and
31:31
Speaker 1: one hundred and eighty eight people loved it.
31:33
Speaker 2: So these things are good.
31:35
Speaker 1: And I actually think those little reels are a gift
31:39
Speaker 1: because it kind of makes it very consumable and pretty clear.
31:44
Speaker 1: So anyway, there's that, mate, Always appreciate.
31:47
Speaker 3: You, pleasure, have a good night.
31:50
Speaker 2: I'll say goodbye to you off here, but i'll see
31:53
Speaker 2: in a week or two. Yeah, see you next time,
31:56
Speaker 2: Thanks buddy.
31:57
Speaker 3: Yeah,