1053-Spatiotemporal Transcriptomic Atlas of Chronic Colitis

Paper Talk · May 30, 2026 · 21m

This study presents a comprehensive spatiotemporal transcriptomic atlas of chronic colitis by integrating longitudinal data from two distinct mouse models. Researchers utilized bulk, single-cell, and spatial RNA sequencing to map how the immune, epithelial, and stromal compartments are rewired during disease progression. The findings reveal a conserved inflammatory signature between murine models and human inflammatory bowel disease, particularly driven by dynamic neutrophil expansion and enhanced epithelial antigen presentation. Spatial analysis further identified three unique inflammatory…