Interorgan Insights: Glucagon-Like Peptide-1 Links Ingestion, Homeostasis, and the Heart

APS Publications Podcast · Mar 4, 2025 · 12m

Glucagon-like peptide-1 (GLP-1), a hormone released from enteroendocrine cells in the distal small and large intestines in response to nutrients and other stimuli, not only controls eating and insulin release, but is also involved in drinking control as well as renal and cardiovascular functions. This review from Comprehensive Physiology details GLP-1's roles in these interconnected systems, highlighting recent findings and unresolved issues, and integrating them to discuss the physiological and pathological relevance of endogenous GLP-1 in coordinating these functions.

Glucagon-Like…