762-Regulatory Networks Governing Human Cortical Cell Fate
This research established a primary culture system to study the gene regulatory networks that control how human radial glia stem cells develop into various brain cells. By utilizing single-cell CRISPR interference (CRISPRi) screening and lineage tracing, the authors examined the functional roles of 44 transcription factors active during cortical neurogenesis. The study identified ZNF219 as a novel repressor of neural differentiation and revealed that NR2E1 and ARX play opposing roles in managing the timing and balance of excitatory versus inhibitory neuron production. Furthermore, the…
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