Episode 31: Depraved Heart

Deadly Divas True Crime Podcast · Jul 17, 2026 · 48m · transcript

Tina leads this episode as we dive into the disturbing case featured on 48 Hours: The Depraved Heart Murder—the death of 25-year-old Sarah Harris and the case against her boyfriend, oral surgeon Dr. James Ryan.

In January 2022, Sarah was found dead inside the Maryland home she shared with Ryan. He claimed she had overdosed after struggling with drugs, but Sarah’s family immediately questioned that explanation. Investigators would eventually uncover evidence involving powerful drugs—including ketamine and propofol—as well as troubling details about Sarah and Ryan’s relationship.

Ryan was…