164-Spatial Transcriptomics Dissecting Tumor-Associated TLS
The paper provide an overview of a comprehensive study using integrated spatial transcriptomic profiling to characterize the cellular features of tumor-associated tertiary lymphoid structures (TA-TLSs) across various cancer types. The research constructed a pan-cancer spatial atlas of TA-TLSs at different maturation states, revealing that IgG+ plasma cells enrich in mature TLSs. Key findings include the identification of CCL19+ perivascular cells that function as lymphoid tissue organizer (LTo) cells promoting TA-TLS formation, and the observation that arterial endothelial cells acquire a…
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