1048-The Ketogenesis-Ferroptosis Axis in leukemia
This study identifies a critical metabolic survival mechanism in leukemic stem cells (LSCs) known as the ketogenesis-ferroptosis axis. Researchers discovered that these malignant cells utilize fatty acid oxidation to produce the ketone body β-hydroxybutyrate (BHB) via the rate-limiting enzyme HMGCS2. This autonomous production of BHB acts as a shield, protecting the cancer cells from ferroptosis, a form of oxidative cell death, by remodeling phospholipids through the epigenetic regulation of FADS2. While this pathway is essential for the maintenance and progression of acute myeloid leukemia…
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