813-Functional Hierarchy of Neocortex Across the Lifespan

Paper Talk · Apr 18, 2026 · 23m

This research establishes a comprehensive normative atlas of the human brain's functional organization, spanning from infancy to one hundred years of age. By analyzing large-scale connectivity gradients, the study reveals that the brain’s architecture is initially anchored by primary sensory systems before differentiating into complex association and control axes during childhood and adolescence. These organizational patterns, which follow nonlinear trajectories, eventually undergo a process of dedifferentiation during aging. The findings demonstrate that these functional hierarchies are…