317-X-ray Nanotomography of Intact Neural Tissue
The research describes a critical advancement in nondestructive X-ray nanotomography (PXCT) for imaging biological tissues at ultrastructural detail, offering a promising alternative to volume electron microscopy. The primary limitation of high-dose X-ray imaging-radiation-induced deformation and disintegration of soft tissue-was addressed through a combination of tailored solutions. Key components include utilizing a cryogenic sample stage, applying nonrigid reconstruction algorithms to computationally correct movement, and embedding samples in a novel, radiation-resistant epoxy resin…
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