Pharma 53: Malaria Chemotherapy - Outsmarting a Shape-Shifter

Clinical Deep Dives · Feb 3, 2026 · 1m

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This episode explores antimalarial therapy as the pharmacology of adaptation versus evasion. Plasmodium changes form, habitat, and vulnerability as it moves between liver, blood, and mosquito-forcing drugs to be chosen not just by species, but by life stage and geography. We trace haem detoxification, folate antagonism, mitochondrial targets, and artemi…