#199 PEEP Explained: Oxygenation, Compliance & Hemodynamics

WhiteBoard Medicine - Emergency And Critical Care · Jan 6, 2026 · 33m

Positive end-expiratory pressure (PEEP) is one of the most powerful — and misunderstood — tools in mechanical ventilation. In this episode, we break down how PEEP works, why it improves oxygenation, and when it can actually harm patients. We’ll walk through: • How PEEP recruits alveoli and improves oxygenation • The relationship between PEEP, lung compliance, and overdistension • How excessive PEEP affects venous return, cardiac output, and blood pressure • The concept of optimal PEEP and how to think about titration at the bedside • Common mistakes clinicians make when setting PEEP 📚…