Micro 30: Clostridium

Clinical Deep Dives · Feb 20, 2026 · 44m

This episode explores the Gram-positive, spore-forming anaerobic rods of the genus Clostridium. Drawing from Murray’s Chapter 30, it centres on organisms whose pathogenicity is defined less by invasion and more by potent exotoxin production.

The narrative moves through the major clinical species:

* Clostridium tetani - neurotoxin-mediated inhibition of inhibitory neurotransmission, producing muscle rigidity and spasm.

* Clostridium botulinum - blockade of acetylcholine release, leading to flaccid paralysis.

* Clostridium perfringens - tissue-destructive toxins causing gas gangrene and food…