1465-Solubilizing Membrane Proteins via De Novo WRAP Design

Paper Talk · Aug 20, 2026 · 21m

Scientists have developed a new class of de novo–designed proteins called WRAPs (water-soluble RFdiffused amphipathic proteins) to solve the long-standing challenge of membrane protein solubilization. These artificial proteins are engineered using deep learning tools like RFdiffusion to "wrap" around the water-repelling regions of membrane proteins, allowing them to remain stable in water without the need for detergents. This method preserves the natural structure and function of the target proteins, facilitating the study of complex molecules involved in signaling, infection, and drug…