407-SpaceBar: Clone Tracing via Spatial Transcriptomics
The paper introduces SpaceBar, a novel biotechnology that integrates cellular clone tracing with high-resolution spatial transcriptomics. By using a library of 96 synthetic barcodes to uniquely label cells, researchers can simultaneously monitor ancestral lineages and gene activity within their physical tissue environments. The study demonstrates the tool's effectiveness in both melanoma cultures and mouse xenografts, revealing how cellular functions are shaped by either internal heritage or external surroundings. A key finding highlights that while most gene expression is dictated by spatial…
The skinny
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