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Iatrogenic Cerebral Amyloid Angiopathy (CAA) and CAA related inflammation (CAA-ri)
The papers summarized focus on Cerebral Amyloid Angiopathy (CAA), particularly the emerging clinical phenomenon of iatrogenic CAA (iCAA). iCAA is hypothesized to occur following the transmission of Amyloid-β (Aβ) seeds (prions) during medical procedures, such as neurosurgery involving cadaveric dura mater. Key points regarding CAA and iCAA include:• Pathogenesis and Latency: The transmission of Aβ results in symptomatic CAA decades later, with a typical latency between exposure and clinical onset ranging from 27 to 59 years.• Clinical Presentation: While initial reports focused on early-onset…
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