1704-Spatial Profiling of Spleen Remodeling in Myelofibrosis
The paper investigates the cellular and molecular mechanisms driving splenomegaly and fibrosis in human and murine myelofibrosis (MF), a chronic myeloproliferative neoplasm. By combining spatial and single-cell transcriptomics with advanced imaging, researchers discovered that reticular cells (RCs) in the splenic stromal niche undergo a pathological shift from supporting hematopoiesis to promoting inflammation and fibrosis as the disease advances. This aberrant remodeling is heavily driven by macrophage-derived signals and complement component C3, which disrupt lymphoid architecture and…
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