Dr. Jason Mouabbi & Dr. Ahmed Elkhanany - SERENA-6, ESR1 Mutations & Molecular Progression

Community Health Media · May 8, 2026 · 46m

What if we could change treatment before scans show progression? In this episode of CHM Conversations, Dr. Jason Mouabbi and Dr. Ahmed Elkhanany explore the impact of ESR1 mutations and the clinical shift toward "molecular progression" in HR+ mBC.

The discussion breaks down the SERENA-6 trial and how early ctDNA detection may allow clinicians to switch therapy before radiologic progression occurs. Dr. Mouabbi and Dr. Elkhanany highlight how precision oncology is reshaping strategy, specifically looking at how oral SERDs like camizestrant can extend endocrine sensitivity and delay more…