1329-Indolelactic Acid Restores Skin Barrier
This research identifies a significant link between the skin bacterium Cutibacterium acnes and the maintenance of a healthy skin barrier in patients with atopic dermatitis (AD). Scientists discovered that AD-associated strains of this bacteria have a reduced capacity to produce indolelactic acid (ILA), a metabolite essential for skin health. Through experimental models, the study shows that applying ILA topically activates the aryl hydrocarbon receptor (AhR) in skin cells, which strengthens tight junctions and lowers inflammatory markers like IL-33. These findings were supported by a clinical…
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