Latest / The BioHub - by Avetix / Episode 61 - Rick Winningham – CEO Theravance
Transcript
- 0:05Welcome back to another episode of the Biohub.
- 0:08Today I'm joined by Rick Winningham, CEO of Theravance
- 0:12Biopharma, a leader who has shaped the biotech and pharma
- 0:15landscape for decades. Rick has been at the helm of
- 0:18Theravance since 2001, guiding the company through major
- 0:22strategic pivots, industry shifts, and groundbreaking
- 0:25developments. With a career including 15 years
- 0:29at BMS, he has LED blockbuster drug launchers, billion dollar
- 0:33partnerships and key industry initiatives.
- 0:36In this episode, we'll dive into the evolution of the industry
- 0:39and how it shapes decision making at Veravance, the impacts
- 0:43of China and India in biotech, the tough market conditions and
- 0:46how to navigate them, and what it takes to inspire the next
- 0:49generation of biotech leaders. So great to have you.
- 0:53Thanks for coming on, Rick. Thanks.
- 0:55Thank you. Very excited about today.
- 0:58Yeah, let's let's dive into it. So first of all, it might be
- 1:02good just to give a bit of a brief snapshot on on who
- 1:05Ferravance are. Sure.
- 1:07Ferravance Biopharma today is a is a commercial stage
- 1:12biotechnology company. We market one product in the
- 1:15United States, a medicine to treat COPD, sometimes called
- 1:19emphysema. So you know, we're strong
- 1:22financially. We've got cash in the balance
- 1:24sheet, as I said, not burning much money.
- 1:27And we have, you know, line on a lot of milestones, cash
- 1:32milestones from programs over the next 12 to 18 months.
- 1:37Yeah, that's, that's awesome. And then like if we just look at
- 1:42your, your journey and your story and then also what, what
- 1:46spired you to pursue a career in biopharma and ultimately come on
- 1:50to fair advance? Yeah, that's, that's a great
- 1:53question because I, I was actually talking with somebody
- 1:56about that this week. And the, you know, when I joined
- 2:01Bristol-Myers, I was, I was working in consulting for a
- 2:05major consulting firm and I, you know, was asked to join
- 2:11Bristol-Myers. And I, I, the sophistication of
- 2:14my analysis was basically, you know, delivering healthcare in a
- 2:20pill or delivering healthcare in, in a shot or injection.
- 2:25That had to be a good thing to do because you were going to,
- 2:29if, if you did that, well, you were going to keep people out
- 2:33of, of high intensive labor environments like hospitals.
- 2:39So that had to be just big picture economically.
- 2:43That had to be a good place to work in.
- 2:45And then, you know, I thought, wouldn't it be, wouldn't it be
- 2:49cool to actually be involved with improving healthcare at
- 2:54scale? And, and it would be something
- 2:58if I got involved with and I, and I was lucky enough to, to
- 3:02spend my career doing it, you know, I could look back and say,
- 3:06wow, you know, I, that was good. I, I did something and I kind of
- 3:10left the place and better, better than I found it so.
- 3:15Yeah. I think you know, like you get a
- 3:19lot of people in this industry who are like very mission
- 3:23driven, like you, you, you ultimately massively fit into to
- 3:27one of those which you've just seen through throughout the time
- 3:30at Veravance. Yeah.
- 3:32And I think, you know, the, the decision to come to leave
- 3:36Bristol-Myers, which is a company that I really loved and
- 3:40I was in AI, was running oncology at the time and
- 3:43virology. And it was a dream job for me
- 3:47because of what we could do, do for patients.
- 3:51And come to a very, you know, startup company in South San
- 3:56Francisco was an incredibly difficult decision.
- 4:01But I was going to go to work for a guy, Roy Vagelos, who who
- 4:07I had, who I'd seen run Merck and who was a real just
- 4:12phenomenal leader with a strong sense of symptom of what's
- 4:19right, how to, how to do things the right way.
- 4:22And so I came to Theravance, not only because I, I wanted to put
- 4:27Mark on my, you know, Mark and working with people on on other
- 4:31medicines, but I came to work. I came to work at Theravance
- 4:35also so I can learn from a doctor.
- 4:37Vagelos And I just thought that, you know, that would be a great
- 4:41thing to be able to, to take away some learnings from, you
- 4:45know, one of the people I thought was a real giant of
- 4:49giant of industry. Yeah.
- 4:52I think that's an interesting topic as well, like that
- 4:54mentorship aspect. And you know, you also joined
- 4:58the company for not necessarily the technology, but but the
- 5:01people like 100%. Yes.
- 5:04And I think we that the basic technology, there was an edge
- 5:08there in the technology, the, the chemical insight that that,
- 5:14that we could potentially lever to discover and then develop
- 5:19medicines and create and, and the work of creating a culture
- 5:24of a company where there wasn't really a company.
- 5:28And the ability to to work with not only Doctor Vagelos, but
- 5:32work with and then hire in extraordinarily talented people
- 5:37that were, as you said, very mission oriented, very mission
- 5:41focused and, and driven by the ability to create new medicines
- 5:49and, you know, leveraging this inside.
- 5:52And it was a, you know, it was a terrifically exciting another,
- 5:55another person, another joined with me.
- 5:58In fact, his name was Pat Humphrey.
- 6:01He was the most cited pharmacologist in the 1990s
- 6:04because of his work on five HT and or serotonin.
- 6:10And Pat and I decided to join Theravant simultaneously.
- 6:14We were having lunch and in Princeton and Doctor Vagelos
- 6:19thought it would be a good idea if we got together.
- 6:22And because he was trying to recruit Pat, who was a head of
- 6:25who was a research background, and me who had commercial and
- 6:28some development experience. And, you know, we basically
- 6:33agreed I would go if Pat went and Pat would go if I would
- 6:36because we had complementary skill sets.
- 6:39And he was another, you know, another person that I could
- 6:43learn from. And not only that, but he was a
- 6:45person who could teach others who who could teach, you know,
- 6:50young scientist, young chemist, young biologist, how what the
- 6:54process of discovery was and how to discover and create new
- 6:59medicines. And you know, without, without
- 7:02Pat's imprint on the company and without his leadership, we would
- 7:06have never become that the and been able to do the drug
- 7:10discovery and have the success that we've had.
- 7:14That's amazing. But let's, let's just talk about
- 7:17like what's happened more recently, specifically pursuing
- 7:22A niche and, and, and the rare disease market, what, what's
- 7:25behind the strategy and also how does it tie to, to the returns
- 7:30you want to create for your shareholders?
- 7:32Yeah. So I think today and, and it's
- 7:35not just today, but in the recent past and in the future,
- 7:39you, you have to, you have to be able to find a niche.
- 7:45We're in the, in the market where you can compete in a
- 7:49superior way. You know it 1520 years and 20
- 7:53years ago in particular, maybe 25 years ago, you know, that
- 7:57wasn't that much of A requirement because the industry
- 8:01wasn't as competitive as it is today.
- 8:05Payers weren't didn't have the influence that they have today.
- 8:09But, but today and in the next 10 to 15 years, certainly if you
- 8:14can't identify a niche with your medicine where you could, you
- 8:18think you can outperform everyone else.
- 8:22And in fact that you have, you have created a medicine such
- 8:25that you can have that niche by yourself for a period of time
- 8:30and not have competition. You will not, you know, by and
- 8:33large you will not be successful.
- 8:35You have to have a superior technology, and then you have to
- 8:39define the niche that you're going to compete in in a
- 8:43superior way such that you will not face terrific competition.
- 8:48Because if you get 3 to 4 players in a given niche today
- 8:52in a commercial market, they'll begin to put pressure on price,
- 8:56returns will decline, and you'll find yourself in a very
- 8:59difficult position as a company. That's such a good point.
- 9:04I suppose, like from an outsider's perspective, it's not
- 9:06something I always think of. At the moment you're running a
- 9:10global trial in a rare nearer indication you know NOH in
- 9:15patients with MSA. What?
- 9:17What are the challenges of of benefits and benefits of doing
- 9:20so? Well, I think that the benefits
- 9:24of of running a global trial as you get to go throughout the
- 9:28world and find in in a variety of countries, the very best
- 9:34investigators, the very best people that understand this
- 9:38given disease and in fact can manage can manage the patient in
- 9:44the study and after the study. You know, that's that's the
- 9:47benefit. So it's an access to fantastic
- 9:51the best of the best in investigators who have chosen to
- 9:54dedicate their lives to the treatment of this disease.
- 9:58And then you the patients. I mean that such that it's a
- 10:02rare disease. So you need to cast your, your,
- 10:07your strategy a bit wide to make sure that you can recruit enough
- 10:11patients into your study to accomplish your clinical
- 10:14objectives. I think that it, it takes, you
- 10:18know, and it still takes a lot of focus and a lot of effort
- 10:21because again, we're a, we're 100 people in that 100 people at
- 10:25Paravance. We part of those people are
- 10:28commercializing medicine for, for COPD in the United States
- 10:32and the other part are really in development drug development,
- 10:36running the clinical trial for amploxatine.
- 10:40But those people that are working clinical development, we
- 10:43don't have a large CRO. We're, we're going in and out
- 10:47and working with these investigative sites around the
- 10:49world and it's a Theravance employee that's really going in
- 10:54and building a relationship and building the ability to work
- 10:57with these sites. Now I think that's good because
- 11:00that gives us a tactile feel of the challenges that the, that
- 11:05the physicians have in treating these patients, the challenges
- 11:09that the patients have with this disease.
- 11:12I mean, I've just spent a month in Europe going, going to the
- 11:16UK, Spain, Italy, Austria, visiting clinical sites.
- 11:23So I could both work with work with the investigators, make
- 11:27sure that we were addressing all the needs that they had so they
- 11:30could optimize their work on our study.
- 11:33And also for me to learn really what are the issues that they're
- 11:36having with, with the treatment of the disease just upfront and
- 11:41personal and without that tactile feel.
- 11:44I think of a disease, particularly rare disease.
- 11:48It, it, it doesn't enable you to optimize the strategy big
- 11:52picture wise. So you know it, it's a challenge
- 11:55to run a rare disease study around the world.
- 11:58But I also think that there's great benefits if you're willing
- 12:02to put the time in to engage with one-on-one with these
- 12:06investigators around the world and learn the challenges that
- 12:11they have in dealing with their patients.
- 12:14I love that. I think it's really, really
- 12:16interesting and fairly unique. And kind of coming back to your
- 12:20point about being mission driven, it really, you know,
- 12:23that is that is it. And then I often hear when
- 12:28you're in the rare disease space, you know, it, it's
- 12:31sometimes hard to, to really get the motivation to, to be like,
- 12:36why are we doing this? You know, if you're working in
- 12:38oncology, everyone's known someone who's affected by by
- 12:42cancer and you don't often have that in, in rare disease.
- 12:45So if you're doing something like that, you you get it
- 12:48basically. Yeah.
- 12:49And I, I, you know, I have a, you know, not so unique, but,
- 12:54you know, my father, my father died of multiple system atrophy
- 13:00and he had severe neurogenic orthostatic hypotension.
- 13:05So I, I sort of began this journey, you know, unfortunately
- 13:10with an understanding of what the disease is and the challenge
- 13:14that it has for patients and their caregivers, you know, the
- 13:18people that are trying to care for them each and every day to
- 13:21get them through a 24 hour period.
- 13:25And I, you know, that that's connection that doesn't even
- 13:31further enhance sort of the mission driven nature of what we
- 13:36do. I I think, I think to be in this
- 13:38business to do what we do, you, you have to put the patient at
- 13:43the center. I mean, you it's, it's a must
- 13:46because if you don't, you'll end up making little incremental
- 13:50decisions that are bad and that eventually, you know, don't help
- 13:55your company to be successful. But if you keep the patient at
- 13:58the center and you keep making the right decisions for the
- 14:01patient, whether it's helping them with reimbursement, whether
- 14:05it's help, considering that you've got to communicate with
- 14:09not only the patient, but the caregiver, you know, that helps
- 14:12you to be successful. So.
- 14:16I think that's awesome advice. Like I always think the dynamic
- 14:20of biotech is, is absolutely fascinating in the fact that,
- 14:23yeah, you know, people are in it to, to make the world a better
- 14:27place. It's patient focus.
- 14:29But also at the end of the day, you've got these shareholders
- 14:32and, you know, it's a business. And like, I was at JP Morgan for
- 14:37the first time at the start of the year and, you know, it
- 14:41really started to click in my head that like, yeah, these
- 14:44people are also smart and they're so science driven and
- 14:46but they're entrepreneurs and they're, you know, it's, it's a
- 14:51crazy dynamic when you break it down.
- 14:54Yeah, you have to get, you have to get a return on investment
- 14:58for your shareholders. You know, that has to be your,
- 15:01your objective. And it's a, it's a very, it's a
- 15:04business that's filled with uncertainty because you know,
- 15:09you're, you're taking a in, in almost all instances, you're
- 15:13taking a product, a chemical or a protein or something and
- 15:18you're putting it in a human being.
- 15:20And that's novel. That has not been done before,
- 15:23and it takes an extraordinary set of of experience to take it
- 15:29from, you know, the bench to to the marketplace and knowledge of
- 15:35a seer of different people with different skill sets, knitting
- 15:39them together to enable that you to enable them to be successful
- 15:43at eventually delivering this medicine.
- 15:45And again, to your point, you've got to you've got to deliver
- 15:50value for your investors. And hence my point about today
- 15:54you have to define a niche where you can compete, where you can
- 15:59deliver something of value that nothing, no one else can
- 16:03deliver. For example, our COPD medicine,
- 16:06you Pellry, it is the only once daily long acting mascarinic
- 16:11antagonist, which is gold standard therapy to open up the
- 16:15lungs or help people to breathe better.
- 16:18It's the only product that's delivered in a nebulizer like
- 16:21that. So now it's now nebulized
- 16:25products only make up about one in 10 COPD patients.
- 16:29But you know, that's OK because there won't be another product
- 16:34like this that enters the market.
- 16:36So as long as we can meet the needs of that one in 10 really,
- 16:41really well, we won't be. We will be successful with you
- 16:44Calorie and our partner will be successful.
- 16:47Likewise amploxatine and treatment of MSA, the treatment
- 16:51of NOH and MSA patients, there's one product here that can do
- 16:56that. And if we can be successful in
- 16:58treating this, these NOH patients with MSA better than
- 17:03anything else, then we will, we will earn a return that's very
- 17:07attractive for our shareholders. But we've got to meet that
- 17:11patient need to do that, yeah. 100% And I want to bring it back
- 17:17to to the industry. You know, you've obviously been
- 17:23at Farivance for a long time, but been part of the biotech
- 17:26industry for a long time. Like what's potentially
- 17:30surprising to you regarding the current environment and, and do
- 17:33you see it as like a, as a challenge or a potential
- 17:36opportunity as well? Well, I think the expanding
- 17:40knowledge of the expanding knowledge of, of biology and
- 17:44disease processes and the number of things, number of different
- 17:47tools that we can use from gene therapy to small molecules to,
- 17:52to achieve better healthcare. I mean, I, I think that's
- 17:55incredibly exciting because you know, even even with 9095% of
- 18:02prescriptions that are written in the United States being
- 18:04generic, there's still a terrific opportunity to improve
- 18:08care with new technology, building on knowledge that of
- 18:12the biology that's, that's, that has been emerging over the last
- 18:1620 years. So, so I think that part of it
- 18:19is exciting and I think the competition it's, it's never
- 18:22been more competitive as I said than it is today.
- 18:26Not only competition in product markets, but competition in the
- 18:31capital markets for for money in order to accomplish what you
- 18:35need to do and the the ability to earn a return for
- 18:40shareholders that you have. So, you know, what's the
- 18:44financial success of this industry has brought has brought
- 18:48a lot of capital into these into these markets, which has created
- 18:53a lot of competition. I mean, it is a it is an
- 18:56absolute example of of what happens in a capitalist economy,
- 19:02which is, you know, profits invite more investment and more
- 19:08investment eventually makes it drives more competition and it
- 19:13gets tougher and tougher. But you can still, if you
- 19:16identify that need and you're the best in class in meeting it
- 19:20and you support your patient, you still can deliver returns
- 19:24and do things that were unthinkable, you know, quite
- 19:28honestly 2025 years ago with regard to healthcare delivery.
- 19:33Yeah. And you know, coming out of JPM
- 19:36as well, China was was quite a big topic of conversation.
- 19:40And like you just said there, they've kind of jumped on that
- 19:42opportunity of, you know, potential gaps in the market.
- 19:48What, what's your view of the country's impact on on global
- 19:51biopharma innovation and how, how does that change potential
- 19:56decision making within the industry as well?
- 19:58It's extraordinary. It's extraordinary because the
- 20:02amount of capital that's been dedicated to biotechnology in
- 20:08China and. I think that you know, when,
- 20:12when you look at the last 10 years, you had a massive up
- 20:16regulation of capital, you know, in the in China being dedicated
- 20:20to the industry. And then for several years you
- 20:23had a massive up regulation in overall in the capital markets
- 20:27with all this, you know, with the with the biotech bubble and
- 20:31all this money flying into to biotechnology to try and create
- 20:35new companies. So you have those two elements.
- 20:38And China has, has now gone from, you know, copying, you
- 20:43know, by and large a great base business of, of, of generics to
- 20:49now a driver of innovation and a source of innovation for the
- 20:54rest of the world. I mean, more and more products
- 20:57that are sold to the United States are likely to be licensed
- 21:02from Chinese companies, Chinese research organizations that have
- 21:06in fact discovered them and done the initial biology.
- 21:09So I think that I think it's very exciting.
- 21:12It puts a real premium on excellence in research because
- 21:17you got a, you're competing with a much, much bigger market for
- 21:21research than what you were doing 20 years ago.
- 21:24So you know, I think that it's, I think it's been a positive
- 21:28move. Obviously it's going to benefit
- 21:31patients tremendously in, in terms of innovation for China
- 21:36and China will support innovation.
- 21:38That's the thing. As they innovate there, they
- 21:41will want a higher and higher premium for intellectual
- 21:45property and I think that will be good for other innovators
- 21:49around the world. Does that change decision making
- 21:54across the industry there and just the success that's come out
- 21:57of China? It it does, yeah, I think it
- 22:00does. And in fact it even changing the
- 22:02decision making, you know what Theravance as long as 1010 years
- 22:07ago where you know, you could see this happening.
- 22:10I can remember talking to the our head of research at the time
- 22:14and, and we were seeing this massive amount of capital that
- 22:18was planned to go into the company creation and innovation,
- 22:24both universities and companies in China.
- 22:27And we thought, you know, there is going to be an extraordinary
- 22:30pool of innovation that can be tapped into, you know, 10 years
- 22:35from now. Well, what does that mean for
- 22:36research that's done in the United States?
- 22:39Well, it has to be much, much, much better today than it was 10
- 22:44years ago in order for it to compete.
- 22:46And it made it tougher for, you know, organizations like their
- 22:50events in research to compete with the overall global market.
- 22:56I mean, where you have to make decisions about where are you
- 22:59going to be competitively superior.
- 23:02And for us it became a choice really of we were going to be
- 23:06competitively superior in taking the medicines that have come out
- 23:10of our research organization and and developing them in a way in
- 23:15niche, in niche markets to satisfy patient need.
- 23:20And that's where our emphasis needed to be, you know, over the
- 23:24last five plus years and that's what we've that's what we've
- 23:27done. But you know, innovation from
- 23:29China is going to provide innovation to the world and
- 23:32innovation to a lot of companies who pick it up and develop it
- 23:35further. Yeah.
- 23:37And and also just like talking about decision making beyond
- 23:41what's happening in China and the innovation coming out of
- 23:44China, does the current market and the potential struggles
- 23:47across the current market affect your decision making at fair
- 23:51events as well? The struggles, you're always
- 23:55going to have struggles. I mean, you know, you're, you
- 23:58know, it's your capitals going to be easy to get that it's
- 24:01going to be hard to get, you know, it goes through different,
- 24:04different cycles. So you do have to plan for, you
- 24:10have to plan for uncertainty and you have to do everything you
- 24:13can in the, in the execution of your strategy, business strategy
- 24:18to, to aggressively manage that uncertainty where you can to
- 24:22reduce the risk for your company.
- 24:24So, so yes, I think that, you know, all across the board, the
- 24:30changes that are happening in industry, you have to take that
- 24:34into consideration when you're executing your, your corporate
- 24:38strategy. You have to take it into
- 24:40consideration when you're, when you're staffing your company,
- 24:43when you're hiring your company. One of the things one of the
- 24:46issues that has occurred because of the biotech bubble and a
- 24:50whole host of companies getting started is that it created an
- 24:55extraordinary demand on, on talented labor.
- 25:00And in fact, you had, you know, all these new companies that
- 25:03were being formed, all of them, depending on where they were,
- 25:06they needed great either great chemists, great biologists,
- 25:09great drug metabolism people. And in fact, there there were
- 25:14not that it wasn't that magically the supply of those
- 25:18great people increased the supply in that short a period of
- 25:22time didn't change at all, but the demand went up
- 25:25significantly. So you had a bit of dilution,
- 25:29you know, of talent because of the domain, the labor demand for
- 25:33all these, all the talented people that you have with all
- 25:36the companies that have been created.
- 25:39And it took, it takes a period of time to get all of the, you
- 25:44know, depending on your speciality to get a group of
- 25:47people up to where they can actually perform at an
- 25:51extraordinary level and develop, you know, to develop them.
- 25:54And I think this dilution of talent that happened in the
- 25:57biotech bubble was real. And it's, it's probably
- 26:00contributed perhaps to somewhat of a lower success rate in, you
- 26:07know, across the board because many people were learning, OK.
- 26:11And and I think now the industry, there's no question
- 26:14over the next 5 to 10 years is going to benefit from that
- 26:17because, you know, people have got the hard earned scars of
- 26:21different challenges that they faced and overcome and they'll
- 26:25be ready for the next, you know, they'll they're it's more likely
- 26:29that they'll take the next piece of technology and make it
- 26:31successful. Yeah, isn't that it's?
- 26:34Amazing. Yeah.
- 26:36Yeah, I think so. And and do you see like a
- 26:39potential catalyst that would move us forward in like the next
- 26:4312, four, 1224 months in terms of the whole industry?
- 26:48You know, I, whether it's a single catalyst or not, I, I, I
- 26:52continue to believe that the pressure on diseases of the
- 26:57aging and particularly diseases like Alzheimer's, Parkinson's
- 27:01disease, we've kind of treated those diseases a bit differently
- 27:05than we did cancer. From a public policy
- 27:08perspective, You know, in the 90's, the NCI doubled their
- 27:12budget twice over a period of 10 years, Significant investment.
- 27:17Rick Klausner and, and Harold Varbas leading those.
- 27:20The NIH and the NCI made terrific investments in the
- 27:24understanding of the basic biology of cancer, and they did
- 27:28that because the government stepped in and funded an
- 27:31extraordinary amount of basic research that then the industry
- 27:35can take some of this basic research and begin to develop
- 27:39new products. Now, most of those products
- 27:41fail, you know, because that's the nature of the industry.
- 27:44But some of them were successful.
- 27:46And those successes built on each other in camp, in the
- 27:50therapy, cancer therapy. That is not what's happened by
- 27:53and large with diseases of the aging of the central nervous
- 27:56system. We haven't had that bolus of
- 27:58capital come in at on basic research.
- 28:01It's more dribbled in over time now.
- 28:05I think that it will, I think people will finally realize
- 28:08that, Oh my gosh, Alzheimer's disease, Parkinson's disease is
- 28:12having a negative effect on gross domestic product.
- 28:15We've got to fix these diseases and the way we fix them is
- 28:19investment in research and then investments in medicine to to
- 28:23treat them. So I see that as a potential
- 28:26catalyst. Yeah.
- 28:28I mean, we're all hoping for it, definitely.
- 28:32Yes, we're hoping for it. Yeah.
- 28:35Can we just look back at your career as well?
- 28:37I just want like 1 moment that that'd be, I think pretty
- 28:41exciting for, for people coming through the industry to hear
- 28:45that, that would, you know, contribute to the way you think
- 28:48and your success. You know what 11 moment that you
- 28:54know what might have been, you know, early in my career when
- 29:00Bristol-Myers licensed in a drug called Taxol to treat cancer,
- 29:08eventually treated ovarian cancer, breast cancer, non small
- 29:11cell lung cancer, Kaposi sarcoma, etcetera.
- 29:16And, and, and the choice to to license this product in from the
- 29:21NCI. It was a difficult choice
- 29:23because there was like no guarantee and it was really made
- 29:27based on a single partial response in an ovarian cancer
- 29:31patient and that one patient that had been treated with
- 29:34everything that there was, which wasn't much at that point in
- 29:37time. And but yet Taxol and they
- 29:40treated it with Taxol had side effects to it, but they saw a
- 29:44partial response. And it was on that strike, the
- 29:47partial response that that the company made the decision to
- 29:51license the product in to reformulate to to find a way
- 29:56because there was no way to manufacture the drug at scale at
- 29:59all. It had to be completely started
- 30:02the manufacturing from scratch from the Pacific Yew Tree, from
- 30:06bark from the Pacific Yew Tree. So bark had to be gathered out
- 30:10of the Pacific Northwest, gathered by the ton to be
- 30:15synthesized into paclitaxel raw material.
- 30:18So and it was all based on this partial response in an ovarian
- 30:24cancer patient that a really smart person said, you know
- 30:28what, that's unique. We don't see that and you know,
- 30:32it lined up, it lined up, you know, billions of dollars of
- 30:36investment and it lined up a medicine that eventually
- 30:40extended survival in ovarian cancer, metastatic breast
- 30:44cancer, adjuvant breast cancer and non small cell lung cancer.
- 30:48So that, you know, that was, I remember that moment like it was
- 30:53yesterday because somebody just said, listen, there's not much,
- 30:58but we need to go after this and we may be able to do something
- 31:02very special. I love that.
- 31:05Yeah. And then look, finally, just to
- 31:08finish, it's a question that we ask all our guests.
- 31:11I think you've got a bit of time to think about it as well, Rick.
- 31:13So if you could have dinner with any scientist or innovator, past
- 31:18or present, who, who would it be and why?
- 31:21Well, I think it'd probably be Isaac Newton, you know, one
- 31:26because I'd probably only get like 20 minutes, you know, of
- 31:30his time. And I would probably only have
- 31:33the chance to answer, ask him to, to try and understand how he
- 31:38thought about things, how he saw what he saw that that ended up
- 31:44translating into, you know, really the basic understanding
- 31:50of how are, you know, the universe is put together.
- 31:54And, you know, I, I just think 20 minutes with him, one, one
- 32:00line of something of how he saw the world and what it was that
- 32:04made him think about X would be, you know, incredibly valuable.
- 32:10I agree. I think that's an amazing
- 32:12answer. And look, thanks so much for
- 32:14coming on, Rick. It's been an absolute pleasure.
- 32:17Thanks for having me and and thanks for the podcast.
- 32:20I hope it's I hope it's been valuable.
- 32:22And you know, obviously I love the industry and whatever I can
- 32:25do to highlight opportunity there, I will.
- 32:28So thank you, Max. No, it's a pleasure.
- 32:30You've got so much wisdom and I love listening to you as well.
- 32:33So look, please everyone like and subscribe to the Bio Hub and
- 32:36thanks again, Rick. Thank you.
- 32:38Take care. You too.