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The Compound That Vomited Before It Could Become Magic

The Compound That Vomited Before It Could Become Magic

A lone human report claims a full psychedelic response to quipazine, a molecule that triggered LSD-like effects in rodents and primates for 60 years yet produced almost exclusively severe nausea in human tests - so how close did science come to a psychedelic that the body refused to tolerate? What stopped researchers from separating its emetic action from its serotonin two-A effects?

In this episode, we lay out the history and data around quipazine across decades of literature, showing what animal models predicted and what the single…

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