1660-Multimodal Mapping of Tissue Genome Architecture
The paper introduce Spatial Hi-C-RNA, a pioneering multimodal technology that simultaneously maps three-dimensional genome architecture and whole-transcriptome profiles within intact tissue sections. By integrating microfluidic barcoding with high-throughput chromatin capture and RNA sequencing, this platform preserves the physical context of genetic regulation at near-single-cell resolution. Researchers successfully applied this method to mouse embryos, adult brains, and human melanoma, demonstrating its ability to link structural features like chromatin loops and A/B compartments to…
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