381-Multiplexed ultrasound imaging of gene expression
This research article introduces next-generation acoustic reporter genes (ARGs) that enable the first "two-tone" multiplexed ultrasound imaging of cellular activity. While traditional ultrasound has been limited to a single signal, scientists used protein engineering and directed evolution to develop two distinct genetic markers, bARG560 and bARG710, which respond to different acoustic pressures. These engineered proteins allow researchers to visualize separate bacterial species and cellular states simultaneously deep within living tissues, such as the mammalian gut or tumors. By overcoming…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.