1117-Restoring Visual Function Optic Nerve Transplantation
Researchers recently developed a surgical technique called hROITON to address complete optic nerve transection in adult rats by transplanting human retinal organoids into the injury site. This study demonstrates that the transplanted organoids survive and integrate, establishing a relay-like bridge that supports neuroanatomical continuity between the eye and the brain. Treated animals exhibited a partial recovery of visual function, evidenced by restored pupillary light reflexes, electrical signal conduction, and visually guided behaviors. By utilizing chemogenetic inhibition, the scientists…
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