1634-Evolution of T-Prolymphocytic Leukemia Progression

Paper Talk · Oct 1, 2026 · 16m

This study utilizes single-cell genomics and whole genome sequencing to investigate the molecular evolution of T-prolymphocytic leukemia (T-PLL) as it transitions from an indolent to an active stage. By analyzing longitudinal patient samples, researchers identified that disease progression is driven by the upregulation of MYC-target gene signatures and a significant increase in energy metabolism, specifically oxidative phosphorylation and glycolysis. The findings also highlight a loss of T-cell receptor signaling importance and a reduction in interactions with the tumor microenvironment…