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Rethinking Cholesterol Risk: What Lean Mass Hyper-Responders Reveal

Is high LDL cholesterol always a red flag?

For a growing group of people known as Lean Mass Hyper-Responders (LMHRs), the answer might not be so black and white.

In this video, Dr. Bret Scher unpacks the science and questions behind LMHRs—metabolically healthy, lean individuals who see a dramatic rise in LDL cholesterol after starting a ketogenic diet. Unlike people with familial hypercholesterolemia (FH), their elevated LDL occurs in a unique metabolic context: low insulin, high HDL, low triglycerides, excellent metabolic health, and comes on only after adopting a ketogenic diet.

🔍 In this…

The skinny

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