1100-Human Nuclear-Embedded Mitochondrial DNA Dynamics
The paper details a comprehensive study of nuclear-embedded mitochondrial DNA (NUMT), which are segments of mitochondrial genetic material that have transitioned into the human and primate nuclear genomes over evolutionary history. Utilizing advanced long-read sequencing and pangenome graph-based detection, researchers identified over 1,100 human NUMTs, distinguishing between fixed events present in all individuals and polymorphic variants that vary across populations. The study reveals that these insertions are not merely "genomic fossils" but dynamic components that can influence gene…
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