1309-Trimodal Imaging of Neuronal Gene Expression
The paper detail the creation of the Imaging-based Multimodal Characterization (IMC) platform, a breakthrough neuroscience tool designed to study individual neurons across three distinct biological dimensions. By integrating in vivo calcium imaging, whole-brain morphological reconstruction, and spatial transcriptomics, researchers can now link a single cell's activity patterns to its physical structure and genetic makeup. The study applies this trimodal approach to the mouse visual cortex, revealing that a neuron's shape and gene expression provide complementary data for predicting its…
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