416-ChatNT: A Conversational Agent for DNA, RNA and Proteins

Paper Talk · Jan 22, 2026 · 17m

Researchers have developed ChatNT, a groundbreaking multimodal conversational agent designed to interpret and analyze complex biological sequences like DNA, RNA, and proteins. By integrating a DNA encoder with a large language model, this system allows users to solve advanced genomics tasks using simple English instructions rather than complex code. The model achieves state-of-the-art accuracy across dozens of tasks, including predicting promoter activity, splice sites, and protein stability. Its unique architecture utilizes an English-aware projection to extract specific biological features…