Latest / Weekly Neurology Deep Dive - A review of recent impactful publications in the field of Neurology
A blood test to distinguish Parkinson's disease and Dementia with Lewy bodies
This research investigates alpha-synuclein (aSyn) strains in Lewy body diseases (LBDs), specifically Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). The study utilized monoclonal antibodies to detect distinct aSyn species, termed strain A and strain B, in various human biological samples. Significantly, higher levels of both strain A and B aSyn were found in the plasma of individuals with PD compared to those with DLB. The authors also found that lower levels of plasma aSyn strain A correlated with a faster rate of cognitive decline in PD patients. Importantly, these plasma aSyn…
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