692-In Vitro Reconstitution of Testicular Niche

Paper Talk · Mar 25, 2026 · 21m

Scientists have successfully developed a method to reconstitute the testicular environment using only mouse pluripotent stem cells, bypassing the need for embryonic tissue. By manipulating specific signaling pathways, researchers guided these stem cells through a bipotential gonadal state into functional testicular somatic cell-like cells (TesLCs). When combined with primordial germ cell-like cells, these induced tissues formed testicular organoids that supported the development of spermatogonial stem cells. These laboratory-grown stem cells were capable of producing mature sperm after…