1555-Decoding Mechanoregulation with Biomimetic kpiCells
Researchers have developed kpiCells, a novel biomimetic platform designed to replicate the complex mechanical and chemical phenotypes of living cells. These artificial cells feature a compartmentalized architecture consisting of a hyaluronic acid-based membrane and a tunable endoplasmic interior, allowing scientists to precisely control stiffness, viscoelasticity, and surface ligands. The study demonstrates that kpiCells can successfully mimic physiological cell-cell interactions, such as the formation of immunological synapses with T cells and the self-assembly of 3D tumor microenvironments…
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