PSYCH 097: Cellular and Molecular Neuropathology of Schizophrenia
Medlock Holmes enters a laboratory containing a brain that appears, at first glance, entirely normal.
There is no tumour.
No haemorrhage.
No obvious area of destruction.
Nothing resembling the unmistakable lesions seen in many neurological diseases.
Yet Holmes knows that normal appearance does not mean normal function.
He begins his investigation at the microscopic level.
Within the prefrontal cortex, the number of neurons is largely preserved, but the space between them has changed. Dendritic branches are less elaborate. Synaptic spines are reduced. The neuropil-the dense forest of axons…
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